Masterpieces of Italy Tour: From David to The Last Supper

View of Piazza Venezia in Rome, Italy

What to expect on this itinerary

Italy is like a treasure chest brimming with art, architecture, and innovation. Experience artistic brilliance with insightful guides accompanying you on an Italy tour personalized to your favorite inspirational masterpieces. Medieval villages overtake hillsides. Ancient arenas continue to permeate the skyline. Frescoes and mosaics retain their bright colors and continue to tell stories through the ages. From Rome to Milan, Florence to Venice, the masters of Italy crafted detailed works that have withstood the tests of time, filling every moment of your luxury Italian tour with a wealth of excellence, wonder, charm, and prestige.

Countries Visited

Italy, Vatican City

Places Visited

Rome, Vatican City, Florence, Assisi, Padua, Venice, Milan

Suggested Duration

10 Days

Customizable Itinerary

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Day 1

Rome – Arrive the Eternal City with a Fascinating Walking Tour and Dinner

Rome represents the brilliance of the classical era and the importance of artistry to daily life beyond the emperors and senators of the empire. Delicate and dramatic frescoes decorate churches. The Spanish Steps shimmer with opulent marble and elegant design. The dome of the Pantheon has inspired architects and artists for two millennia, including the legendary Michelangelo and Brunelleschi. Your flight lands at Rome Fiumicino Airport. Your private transfer greets you upon your arrival and escorts you to a gorgeous hotel in the historical city center. Locals and visitors wander along the designer shops along Via del Corso.

The scent of strawberries drifts out of a gelaterie, emanating from the fruity gelato. You take a moment to settle into the comforts of your luxury hotel set inside a former magnificent palace. Your guide greets you in the lobby, eager to introduce you to the masterful works of Rome on a walking tour through the city center. Consider learning more about the top Italy travel agents who will help design, create, and guide your dream Italy vacation. You can see the golden façade of Castel Sant’Angelo across the bridge over the Tiber River. The structure began as a mausoleum for Emperor Hadrian and was converted into a papal fortress centuries later. The 10 angelic statues line the cobblestone bridge, each designed with a careful eye to detail by master sculptor Bernini. His work guides your exploration of the city center, as you make your way to Piazza Navona to view the elaborate Fountain of the Four Rivers, which Bernini also designed.

What's Included:

Transfer
Accommodation
Tour
Day 2

Rome – Enjoy the Rich History of Rome on a Private Guided Full Day Tour

Day 3

Rome – Visit Vatican City and the Remarkable Churches Decorating Rome

Day 4

Florence – Wander Historic of Assisi and Enjoy a Fabulous Tour of Florence

Day 5

Florence – Explore the Uffizi, Pitti Palace, and Hidden Artisan Workshops

Day 6

Florence – Discover the Accademia, San Marco Church, and Central Market

Day 7

Venice – Relish the Churches and Cuisine of Bologna and Art of Padua

Day 8

Venice – Absorb the Art and Architecture on a Full Day Tour of Venice

Day 9

Milan – Venture to Milan to View the Duomo and Santa Maria delle Grazie

Day 10

Milan – Depart for Home

Trip Highlights

  • Discover the brilliance of Italian masters up-close and in person under the instruction of expert guides in art history, culture, and style
  • Visit the Vatican Museum to stand beneath the iconic images draping over the walls and ceiling as painted by Michelangelo in the 16th century
  • Trace the evolution of sculpture in Florence to enjoy the masterful works carved out of marble, including standing beneath Michelangelo’s David
  • Revel in the feeling of grandeur and amazement as you stand in front of Leonardo da Vinci’s masterpiece The Last Supper in Santa Maria delle Grazie
  • Witness the beginnings of the Renaissance while visiting the Scrovegni Chapel in Padua, where Giotto first applied human characteristics upon divine figures
  • Wander the galleries of Villa Borghese, home to one of the greatest private collections of art
  • Traverse the fabulous halls of the Accademia in Venice in search of the fabled Venetian masters inside the galleries in which they studied
  • Relish the unique ambiance of great Italian cities whose architecture is as masterful as the artwork which they contain 

Detailed Description

The masters of Italian art have shaped history through the way they captured allegories, biblical tales, and daily life. Your personalized Italy tour immerses you in the artworks of the past on a 10-day tour highlighting masterpieces, from the Colosseum to the Trevi Fountain, David to the frescoes in the Scrovegni Chapel. The thrilling exploration begins with your arrival in Rome. Your private transfer greets you at Fiumicino Airport and escorts you to a gorgeous hotel within the historical city center. Discover the iconic fountains and piazzas of the city with a private guide and explore the ancient architecture and preserved walkways winding between the Forum and Palatine Hill. Witness the elaborate collection of works inside the Vatican Museum, including works of Raphael and Michelangelo. Stroll through the elaborate galleries of the Borghese Villa to view one of the world’s most elaborate private art collections.

Visit the town of Assisi, in Umbria to follow in the footsteps of St. Francis. The basilica remains a dramatic piece of architecture home to fascinating frescoes and the antique tomb of the eponymous saint. Once in Florence, the images of the Renaissance spring to life. Enjoy a walking tour of the city’s endless wealth of structures designed by master architects, from the Medici chapel at San Lorenzo to the idyllic dome of the cathedral at the heart of the historic center crafted by Brunelleschi. Visit the masterpieces housed in the Uffizi and Pitti Palace before meeting with contemporary artisans preserving the traditions of quality goods handcrafted in Florence. Explore the Central Market for an enriching, flavorful experience and follow the historic evolution of sculpting in Florence, reaching the pinnacle with Michelangelo’s David.

Bologna is a city regarded for its cuisine but retains elements of masterful artwork and architecture on display around the city center. Stop in the quiet city of Padua en route to Venice to see Giotto’s masterworks decorating the Scrovegni Chapel, which various artists attribute bringing in the birth of the Renaissance. Venice is a city of grandeur embodied in the gorgeous palazzos and charming neighborhoods. Enjoy the graceful ambiance with tours of the Accademia Gallery and churches embedded with historical artwork, including St. Mark’s Basilica. You reach the marvels of Milan for a guided tour to take in the magnificent cathedral and The Last Supper by da Vinci. Your private transfer escorts you to Malpensa Airport on the final day of your Italy tour with plenty of time to check into your flight home.

Consider browsing our other Italian tours to gain further inspiration in perfecting your own dream Italy vacation of a lifetime. 

Starting Price

$4,500 per person (excluding international flights)

Your Zicasso trip is fully customizable, and this sample itinerary is a starting place for your travel plans. Actual costs are dynamic, and your selection of accommodations and activities, your season of travel, and other such variables will bring this budget guideline up or down. Throughout your planning experience with your Zicasso specialist, your itinerary is designed around your budget. You can book your trip when you are satisfied with every detail. Planning your trip with a Zicasso travel specialist is a free service.

What's Included

  • Accommodations
  • In-country transportation
  • Some or all activities and tours
  • Expert trip planning
  • 24x7 support during your trip

Your final trip cost will vary based on your selected accommodations, activities, meals, and other trip elements that you opt to include.

4.9

Verified Traveler Reviews

Based on 896 reviews

Italy Trip Review: Rome, Florence, Tuscany, Amalfi Coast, Pope Francis’ Funeral, Wine, Cuisine, Culture, Museums, Relaxation, 10 Nights

Zicasso’s tour operator planned the most amazing trip to Italy for us! My requirements were culture, romance, and relaxation. She delivered on every aspect. Although we missed our tour of the Vatican due to the Pope's funeral, my husband and I actually attended his funeral!! Our hotel, though planned many months before, was next to the basilica where Pope Francis was laid to rest. Talk about being a part of history!

We stayed in a beautiful converted villa to boutique hotel in Florence; got whisked away through the Tuscan countryside in a vintage Fiat 500; took cooking classes; sipped lovely wine, accompanied by excellent lunches on our winery tours; soaked in Italy's rich culture and museum scene; and even ticked the relaxation box by spending time by the pool, in the spa, and resting on our large deck overlooking the Amalfi coastline.

Every tour guide was extremely knowledgeable and personable, and it was evident they loved their jobs. Between memories of the boat ride along the Amalfi Coast, tips from the cooking classes I have already started using at home, and the cases of wine we are eagerly awaiting delivery of, my husband and I will forever hold Italy in our hearts and la dolce vita it provided us. 

Talk with our tour operator; you will be glad you did!

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Switzerland, Italy Solo Vacation Review: Zurich, Lucerne, Interlaken, Zermatt, Lake Como, Venice, Florence, Sorrento, Amalfi, Rome, Skydiving, Gondola Ride, Amalfi Coast Cruise, Scenery, Nature, Local Cuisine, 3 Weeks

My first solo trip was something I had dreamed about for years. I wanted it to be more than sightseeing. I wanted adventure, comfort, safety, and freedom without the stress of planning it all alone. Through Zicasso, I was connected to two specialists and Zicasso's travel consultant stood out immediately. She delivered an itinerary that gave me everything I asked for and more: maximum cities, maximum fun, and maximum value, all without compromise.

Before deciding, I researched and compared tours, packages, and individual prices online. The travel consultant’s proposal came out on top for value and content. While the other agent offered fewer cities and activities at a higher price, her plan was ambitious without being overwhelming. She booked my trains, arranged private transfers where needed, and selected boutique-style hotels that exceeded expectations. I was honestly surprised at how good they were. I stayed at hotels in Interlaken, Florence, and Sorrento. Each was clean, comfortable, and perfectly located for exploring. I had prepared myself for budget trade-offs, but instead, I found thoughtfully chosen hotels that balanced affordability with real quality.

Every document, train ticket, and activity confirmation was uploaded into the app. It became my lifeline throughout the trip, with every detail at my fingertips. The structure gave me confidence, while still leaving me free to explore.

Switzerland came first: Zurich, Lucerne, Interlaken, and Zermatt. Each city felt like stepping into a postcard. Interlaken gave me the adrenaline rush of skydiving, while Zermatt charmed me with its close-knit magic and alpine beauty. Italy unfolded with equal ease: Lake Como, Venice, Florence, Sorrento, Amalfi, and Rome. Every destination felt curated, yet natural, from gondola rides in Venice to boat tours on the Amalfi Coast.

What I loved most was the balance between structure and freedom. Pre-booked activities and restaurant reservations gave me a strong framework, but I could just as easily decide to spend an afternoon wandering Florence, eating gelato, or sitting in a piazza. The rhythm of the trip was perfect, structured enough to tick off bucket-list highlights, yet relaxed enough to feel like a real vacation.

Food was freestyle, but memorable. Highlights included a Japanese-Peruvian restaurant in Zurich with its elegant Japanese-Peruvian flavors, a different Japanese restaurant, a restaurant in Como with its modern fusion menu, an Indian restaurant for comforting classics, and international favorites like those in one of the restaurants in Rome. Between those meals and plenty of gelato and crepes, every stop added its own flavor to the journey.

As a solo traveler, safety mattered. I felt comfortable walking around in the evenings and was usually back in my hotel by 1am to stay rested for the next day. What really gave me peace of mind was the travel consultant’s constant support. Communication was fast and responsive. I never had to wait long for answers, whether through the app or email. There was a moment when I made a mistake with the trains and missed an activity. She immediately stepped in and worked to reschedule it or secure a refund that same day.

Earlier in the planning process, I also had a card issue due to an address error. Even though policy would not normally allow it, she and her team patiently waited until I received the refund before finalizing the booking, just weeks before my trip. That flexibility and care spoke volumes.

The difference was clear. She used my budget to its fullest potential, giving me more destinations, more experiences, and better hotels than the alternative option. She managed to combine the efficiency of a fully organized tour with the freedom of independent travel. Everything was planned, yet everything was still mine to shape.

This trip was everything I wanted: good food, beautiful views, safety, and absolute reliability. It was an organized journey with freestyle flexibility, which is exactly what solo travelers dream of. The travel consultant’s planning let me chase adventure while always knowing I had a safety net. Switzerland and Italy gave me memories I will never forget, but it was the behind-the-scenes planning that made it possible. If you want a trip that is your way, your budget, your pace, but without the endless hassle of managing it yourself, the travel consultant at this agency is the person who can make it happen. My first solo trip became my dream trip and that is the highest praise I can give.

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Italy Trip Review: Rome, Florence, Venice, Pompeii, Tuscany, Private Tour, Vatican, Colosseum, Cooking Class, Organic Farm, Cheese Making, 8 Nights

Overall, this may be too much, but we were happy to have written it down as it allowed us to relive the experience. This was a wonderful trip and we absolutely recommend Zicasso and our travel agent. We are already thinking about our next adventure in Italy. Here are the details...

Planning: Zicasso’s travel agent did a wonderful job of helping us plan a trip, making adjustments and ensuring the adventure turned out perfectly. We interviewed several approaches to planning the trip and our choice with Zicasso’s tour company was the right one for us. The trip app was great and kept everything right at our fingertips. We will definitely reach out to this travel agent when we return to Italy.

Food: How is it that when we stopped on the highway to Florence for a coffee, the food was as good as any high-end restaurant in the United States—organic, fresh, and tasty. One of our crew is gluten sensitive in the United States… in Italy, it’s not the gluten, it’s the chemicals used in the United States. We ate bread at every meal and had no problems. We learned that more simple fare is better fare and just amazing. No need for exotic tasting of cheese, bread, wine, pasta, salad, olive oil, vinegar, with fresh vegetables in the sauce, is all one ever needs… until the gelato at least twice a day.

Logistics: The logistics were great and absolutely essential for first-time travelers. There were guides and drivers to meet us at every stop. They seemed to know what we looked like and were just so very helpful.

Guides: Great choices across the board! Their knowledge and love of their various cities was detailed and charming. It was clear that each city fancies itself as the origin of culture and much more. We loved the perspectives and personalities of the people, and of our guides in Rome, Florence, the Tuscan farm, Venice, the Venice water tour, and Pompeii.

Drivers: Our three drivers, especially the one who got stuck with us on the way to Florence due to an auto accident. He really had an extended day and we really appreciated his patience. We got to know him a little and he was delightful.

Travel by train: It was so easy, fast, and comfortable. We loved the time together and the scenery. The added benefit of the lounge made a big difference from the busyness of the train station. We loved this, all at 300 km/h!

Hotels: The hotels were exactly as described—centrally located, convenient, and very comfortable.

Rome: The best beds and staff!

Florence: The best location—convenient to shops/cafés and breakfast.

Venice: Great location, with window views of the canals; it was very nice, but a bit dated in decor in the lobby. We would still stay there next trip!

Planning and sites visited: Overall, each of the cities and sites were outstanding. They gave us a great insight into Italy as a country, as well as its culture and people. Everyone we engaged with (including hotel staff, restaurants, and locals) was friendly, helpful, and engaging. The pervasiveness of English speakers was incredible. Our single-language approach is something we need to work on in the United States! We always felt safe and well taken care of. The added benefit of this support was that it allowed all of us to focus on the city and countrysides, not the driving. It may cost a bit more, but we felt it was totally worth it.

Roma: Here is the only mistake we made in planning our trip. Doing the Vatican and ruins/Colosseum in the same day is too much. This was clearly our decision and our travel agent suggested that it was “a lot.” Having said that, the pre-purchase and guide is clearly the way to go in whatever city you visit. The three sites are incredible.

Pompeii: We thought this would be neat to see, but not as amazing as the other sites…we were wrong. Pompeii is an incredible site and the pace of the tour was just about right for us. This is a place where you can walk the streets where people have walked since long before Christ. The opulence of their living (steam baths, frescos, statues, and mosaics) is incredible.

Tuscan countryside: The organic farm and cheese-making visit, including a quick trip to Pienza, was an absolute highlight. The lunch was fantastic and inspired us to eat organic! We also loved that to get to the farm you had to travel on gravel roads (well maintained, by the way) and got to see working farms.

Pienza is a beautiful, small village where we could spend an entire day exploring. Next visit, we will carve out a day to shop there and spend the night. There was so much to do in a limited time!!!

Florence: It's just beautiful. The work by Michelangelo just defies explanation and leaves you breathless. The churches are a monument to the wealth and dedication of generations of craftsmen engaged in centuries of work. The cooking class was wonderful and fun, and there was so much food. Making your own tiramisu, pasta, chicken dishes, and sauces was just wonderful.

Venice: We skipped the gondola ride because the tour of the Grand Canal was just incredible. Some of us were a bit spooked by the narrow “streets” or, better yet, passageways. However, we all loved the tour and exploring. One of our crew took off later in the day after the tour and tried to get lost… successfully. But with a bit of iPhone maps and the kindness of the people, they found cafés, open-air markets, an antique shop, children playing football, and a delightful adventure.

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Italy Family Vacation Review: Venice, Verona, Florence, Tuscany, Siena, Rome, Biking, Cooking, Wine Tasting, Olive Oil Experience, 10 Nights

Zicasso's travel company planned the most amazing trip to Venice, Verona, Florence, Tuscany, Siena, and Rome for our family of five. It was the best trip I've ever taken, and having all the details covered by them and plans and tickets sent to us via WhatsApp allowed us to really live in the moment and not have to think about what was next. I loved every second. I cannot wait to plan another trip to Italy to experience the southern half of the country.

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Italy Tour Review: Rome, Florence, Venice, Private Tours, 12 Nights

Our recent trip to Rome, Florence, and Venice, planned by Zicasso’s travel specialist and her team, was nothing short of exceptional. Every detail was handled with care, precision, and an obvious commitment to excellence. The hotels were truly top rate, perfectly located, and impeccably chosen to enhance the experience of each city. The tour guides were extremely knowledgeable, engaging, and clearly passionate, adding depth and context that made each destination come alive.

What truly set this trip apart was the level of service. From seamless transfers to on-the-ground assistance, everything felt effortless. The recommendations and tips provided along the way were incredibly useful and allowed us to experience each city with confidence and ease. The assistants who helped guide us through logistics and navigation were attentive, professional, and reassuring, making the entire journey feel like true white-glove service from start to finish.

The travel specialist and her team exceeded every expectation. Their planning, responsiveness, and attention to detail transformed an already incredible itinerary into an unforgettable experience. I would recommend them without hesitation to anyone looking for a flawlessly executed, high-end travel experience.

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Italy Luxury Family Tour Review: Milan, Padua, Venice, Florence, Tuscany, Siena, Assisi, Cascia, Rome, Vatican City
"The tour was wonderful and well organized, thanks to our terrific Zicasso travel advisor."

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Customizable Itinerary

This is a sample itinerary to inspire a personalized trip designed with your travel specialist.

28,000+ Verified Traveler Reviews